It seems like everyone from the New York Times to NPR is coming out with Best Books of the Year lists right now. As "best" is subjective, I instead offer you some of my favorites in various categories. Most of these are 2010 books, but are some are older books that I first read or listened to this year.
Post-Apocalyptic Fiction (no zombies): The Passage, Justin Cronin
Post-Apocalyptic Fiction (with zombies): The Reapers are the Angels, Alden Bell, Feed, Mira Grant